What can science tell us about the Kennedy assassination and the investigations that followed‌? The 1963 murder, in broad daylight in front of hundreds of witnesses, was a homicide investigator’s best-case scenario. Yet somehow the JFK assassination became a forensic nightmare, plagued by mishandled evidence, a controversial autopsy and, incredibly, a prime suspect murdered while in police custody before he could be tried — all of it captured on film. NOVA follows a group of experts attempting to unravel the lingering mysteries of the assassination.